Infrequent alterations of thep15, p16, CDK4 andCYCLIN D1 genes in non-astrocytic human brain tumors
نویسندگان
چکیده
منابع مشابه
An Immunohistochemical Study of Cyclin D1 Expression in Astrocytic Tumors and its Correlation with Tumor Grade
Background & Objective: Glioblastoma-multiforme is the high grade form of astrocytic tumors with a short survival time, which are the most common type of brain tumors. Therefore, finding new therapeutic options is essential. Cyclin D1 is expressed in some human malignancies and can be a potential target for therapeutic intervention. The aim of the present study was to determine...
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متن کاملThe p16-cyclin D1/CDK4-pRb pathway and clinical outcome in epithelial ovarian cancer.
A significant positive association has been reported between p16 expression and clinical outcome for epithelial ovarian cancer patients. However, there is a reciprocal correlation between genetic alterations of single members of the p16-cyclin D1/CDK4-pRb pathway (G1 pathway). Simultaneous evaluation of these four elements may produce a better prognostic factor than p16 alone. We studied the pr...
متن کاملp53 protein alterations in adult astrocytic tumors and oligodendrogliomas.
BACKGROUND p53 is a tumor suppressor gene implicated in the genesis of a variety of malignancies including brain tumors. Overexpression of the p53 protein is often used as a surrogate indicator of alterations in the p53 gene. AIMS In this study, data is presented on p53 protein expression in adult cases (>15 years of age) of astrocytic (n=152) and oligodendroglial (n=28) tumors of all grades....
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 1996
ISSN: 0020-7136,1097-0215
DOI: 10.1002/(sici)1097-0215(19960503)66:3<305::aid-ijc6>3.0.co;2-2